【摘要】 目的 :探讨乌司他丁对酸吸入性急性肺损伤早期所诱发的肺局部炎症因子的影响及意义。方法 :SD大鼠 30只随机分为对照组 (10只 ) ,酸吸入损伤组 (10只 )和乌司他丁 (UTI)治疗组 (10只 )。建立大鼠酸吸入性急性肺损伤模型。用放射免疫法测定术后 5h肺组织匀浆上清液中肿瘤坏死因子α(TNF α)、白细胞介素 8(IL 8)两种细胞因子的含量。同时进行肺湿干重比值 (W/D)和血气的测定。结果 :治疗组的W /D值显著低于损伤组 (P <0 .0 1)。治疗组炎症因子升高幅度明显低于损伤组 (P <0 .0 1) ,且治疗组与对照组之间比较无统计学意义 (P >0 .0 5 )。治疗组血氧分压 (PaO2 )高于损伤组 (P <0 .0 1)。结论 :UTI可减轻酸吸入早期由细胞炎症因子介导的急性肺损伤。更多还原

【Abstract】 Objective To determine the effect of ulinastatin (UTI) on blocking the development of acute lung injury (ALI) induced by acid aspiration in the early period. Methods The SD rats were randomly divided into 3 groups: control group (n=10), injury group(n=10), and UTI-treated group(n=10).The rats in the control group were injected intrabronchialy saline while the other 2 groups were injected HCl. The UTI-treated group was injected UTI at 4×10 4 U/kg after acid instillation.Blood gas as well as wet/dry weight ratio(W/D) of the left lung was measured. The changes of IL-8 and TNF-α levels in the pulmonary tissues were determined by enzyme-linked immunosorbent assay. Results The result of blood gas analysis in the UTI-treated group was much better than that in the injury group (P<0.01).W/D and IL-8,TNF-α levels were lower in the UTI-treated group than those in the injury group significantly (P< 0.01 ), and there was no difference between the UTI-treated group and the control group in IL-8 and TNF-α levels(P>0.05).Conclusion UTI administration can lessen the development of ALI induced by acid aspiration in the early period.更多还原