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不同剂量CpG序列对仔猪的免疫增强效果
Effect of different dosages of CpG motifs on immune responses in piglets
【摘要】 以伪狂犬病毒为模式病毒,按照仔猪体质量分别将100、10、1μg/kgCpG序列同猪伪狂犬疫苗联合免疫接种仔猪,检测仔猪的体液及细胞免疫反应.试验结果表明:不同浓度的CpG序列均能显著提高仔猪的特异性抗体滴度、白细胞介素(IL) 2诱生活性以及淋巴细胞增殖反应,证明CpG序列能显著增强仔猪对常规疫苗的免疫应答能力.
【Abstract】 Piglets were inoculated with CpG motifs and pseudorabies attenuated vaccine simultaneously, the CpG motifs inoculation dosages were 100, 10, 1 μg/kg, respectively. The titer of specific antibodies to pseudorabies attenuated vaccine, the proliferation of lymphocytes and induced IL-2 activities were assessed. The results showed that the above-mentioned immune response of the piglets to vaccine with different dosages of CpG motifs added was significantly stronger than conventional immunization.
【关键词】 胞嘧啶鸟嘌呤二核苷酸序列；
免疫应答；
仔猪；
伪狂犬病活疫苗；
【Key words】 CpG motifs； immune response； piglets； pseudorabies attenuated vaccine；
【Key words】 CpG motifs； immune response； piglets； pseudorabies attenuated vaccine；
【基金】 广东省农业攻关项目(2003B21403);广州市重点攻关项目(2003ZR E0221)
- 【文献出处】 华南农业大学学报 ,Journal of South China Agricultural University , 编辑部邮箱 ,2004年01期
- 【分类号】S852.4
- 【被引频次】9
- 【下载频次】214