【摘要】 目的　研究骨桥蛋白在胃癌组织中的表达及其与诱导型一氧化氮合成酶表达的关系。方法　应用免疫组织化学方法检测胃癌组织中骨桥蛋白和诱导型一氧化氮合成酶的表达 ,并进行随访。结果　 66例胃癌组织中骨桥蛋白和诱导型一氧化氮合成酶表达的阳性率分别为 72 .7% ( 4 8/66)、75 .7% ( 5 0 /66) ,骨桥蛋白的表达与肿瘤浸润深度、肿瘤直径、淋巴结转移程度及有无远处转移有关 ,iNOS的表达与肿瘤浸润深度、肿瘤直径、淋巴结转移程度有关。结论　骨桥蛋白在胃癌组织中表达均增强 ,能够作为反映肿瘤的生物学特性 ,评估预后的重要参考指标。骨桥蛋白和iNOS表达有协同作用。更多还原

【Abstract】 Objective To investigate the expression of osteopontin in gastric cancer and it’s correlation with inducible nitric oxide synthase.Methods The expression of osteopontin and inducible nitric oxide synthase was examined using immunohistochemistry method.Meanwhile the follow-up was done.Result In 66 gastric cancer tissues, the positive expression rate of osteopontin and inducible nitric oxide synthase is 72.7%(48/66)、75.7%(50/66)respectively. Osteopontin expression is related with invasion depth, tumor diameter, lymphnode and distant metastasis. Inducible nitric oxide synthase expression is related with invasion depth, tumor diameter, lymphnode metastasis and has no relation with distant metastasis.Conclusions Osteopontin was overexpressed in gastric cancer. Its expression can show the biological characteristics of gastric cancer and can be the important indicator of prognosis. The expression of osteopontin and inducible nitric oxide synthase is coordinated in gastric cancer.更多还原