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甲苯二异氰酸酯对细胞因子的影响
Study on effects on cellular gene of toluene diisocyanate
【摘要】 对甲苯二异氰酸酯对免疫系统的毒性作用展开研究,并对其免疫毒性机制进行了探讨.采用双抗体夹心酶联免疫吸附实验观察了甲苯二异氰酸酯对小鼠血清中白介素-4、白介素-5和粒细胞-巨噬细胞集落刺激因子质量浓度的影响.为确定环境中TDI的安全量或容许量,为评价该化合物的健康危险性和生态风险性,为环境执法和确定防治对策提供坚实的科学理论依据.
【Abstract】 To study on toxic action and mechanism of toluene diisocyanate on immune system, this paper mainly discussed the mechanism of toluene diisocyanate on immune system. Adopted ELASA, this experiment observed that effect of toluene diisocyanate on conglutinate molecule, such as IL-4, IL-5, GM-CSF. To ensure the safe dose or allowable dose of toluene diisocyanate and evaluate its health risk and ecosystem risk, this paper will provide the solid science theories basis for confirmation of environmental law and preventing plan.
【关键词】 甲苯二异氰酸酯;
细胞因子;
免疫;
毒性;
机制;
【Key words】 toluene diisocyanate; cellular gene; immune system; toxicity; mechanism;
【Key words】 toluene diisocyanate; cellular gene; immune system; toxicity; mechanism;
【基金】 国家自然科学基金资助项目(30271108).
- 【文献出处】 哈尔滨商业大学学报(自然科学版) ,Journal of Harbin University of Commerce(Sciences Edition) , 编辑部邮箱 ,2004年05期
- 【分类号】R114
- 【被引频次】5
- 【下载频次】78