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盐酸头孢他美酯及片剂的HPLC测定

Determination of Cefetamet Pivoxil Hydrochloride and Its Tablets by HPLC

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【作者】 章春艳马玉崇

【Author】 Zhang Chunyan, Harbin Pharmaceutical Group Co Ltd General Pharm Factory(150086)

【机构】 哈药集团制药总厂哈药集团制药总厂 (150086)(150086)

【摘要】 目的:采用 HPLC 法测定盐酸头孢他美酯原料药及其片剂的含量。方法:以 Nova-PakC18为色谱柱,乙睛-甲醇-水-磷酸盐缓冲液(360:95:500:45)流动相,检测波长为263nm。结果:线性关系 r=0.9999,平均回收率为99.94%,RSD=0.44%(n=5)。结论:方法简便、准确,适用于该产品的质量检验分析。

【Abstract】 Objective:Cefetamet pivoxil hydrochloride and its tablets were determined by a new HPLC method.Method:The separation was performed on a Nova-Pak C18 Column.The mo- bile phase was composed of acetonitrile-methanol-water-phosphate buffer(360:95:500:45). The UV detector was set at 263 nm Results:The average recovery was 99.94%(RSD=0.44%,n =5)with good linear relationship (r=0.9999).Conclusion:The method was simple and accurate and can be used for the quality control of cefetamet pivoxil hydrochloride and its tablets.

  • 【文献出处】 黑龙江医药 ,Heilongjiang Medical Journal , 编辑部邮箱 ,2004年04期
  • 【分类号】R927
  • 【被引频次】2
  • 【下载频次】57
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