【摘要】 目的 :探讨冠状动脉粥样硬化患者血浆中C -反应蛋白、同型半胱氨酸及内皮素在动脉粥样硬化的发生发展过程中的作用 ,以及上述三种物质之间的相关性。方法 :对 5 0例冠状动脉粥样硬化患者及 30例正常对照者采用免疫增强的投射比浊法及高效液相色谱法 ,分别检测了外周血中C -反应蛋白、同型半胱氨酸及内皮素的含量 ,并对其进行对比及相关性分析。结果 :冠状动脉粥样硬化患者组 (试验组 )血浆中C -反应蛋白、同型半胱氨酸及内皮素含量分别是 :5 .83± 2 .77(mg/L) ,1 6 .82± 6 .81 (μmol/L) ,83.1 7± 2 9.6 3(ng/L) ,而正常对照组上述三种物质的含量分别是 :0 .87± 0 .5 0 (mg/L) ,9.93± 2 .87(μmol/L) ,4 6 .6 7± 1 4 .4 1 (ng/L) ,对应两组间差异均具显著性 (P <0 .0 5 ) ,C -反应蛋白、同型半胱氨酸与内皮素的相关系数分别为 0 .732及 0 .892 ,均呈正相关。结论 :C -反应蛋白、同型半胱氨酸及内皮素对冠状动脉粥样硬化的发生发展有促进作用 ,对其检测有实用的临床价值更多还原

【Abstract】 Objective: To research the role and relationship between changes of the content of C-reaction protein(CRP), homocysteine(Hcy) and endothelin(ET) in patients with coronary atherosclerosis. Methods: 50 cases of C-reaction protein, homocysteine and endothelin in patients with coronary atherosclerosis and 30 cases of them in normal persons as control were detected by immune-reinforced projective turbidimetry and high performance liquid chromatograpy. Results: In patients’ plasma with coronary atherosclerosis bundle CRP, Hcy and ET levels were 5.83±2.77(mg/L),16.82±6.81(μmol/L),83.17±29.63(ng/L),the controls were 0.87±0.50( mg/L ),9.93±2.87(μmol/L),46.67±14.41(ng/L),there were significant differences between them(P<0.05),there were positive correlation between CRP and ET, Hcy and ET(r=0.732,0.892).Conclusion: CRP, Hcy and ET contribute to the development and growth of coronary atherosclerosis, there are utilitarian clinical value of their detection.更多还原