【摘要】 目的 :探讨NO在儿童抽动障碍发病机制中的作用。方法 :测定 5 0例抽动障碍患儿血浆NO水平 ,其中暂时性抽动 1 4例 ,慢性多发性抽动 2 1例 ,抽动─秽语综合征 1 5例 ;单纯性抽动 2 4例 ,抽动并多动障碍 2 6例。结果 :①抽动障碍患儿NO水平明显高于对照组 (P <0 .0 1 )。②慢性抽动障碍和抽动─秽语综合征血浆NO水平 ,分别于对照组血浆NO水平比较 ,结果前 2组血浆NO水平明显高于对照组和暂时性抽动组 (P <0 .0 1 ) ,对照组与抽动组比较无显著性差异 (P >0 .0 5 )。③抽动并多动障碍血浆NO水平明显高于单纯性抽动组 (P <0 .0 1 )。结论 :儿童抽动障碍存在NO水平的变化 ,NO可能参与抽动障碍的病理生理过程更多还原

【Abstract】 Objective: To investigate the role of some Nitric Oxide( NO) in pathological mechanism of tic disorders (TD) in chidren .Methods: To test the plasma level of NO in 50 children with TD and in 45 normal children as control group .Among sick children , 14 cases were transient tic disorders; 21 cases were chronic tic disorders , 15 cases with Tourette’s syndrome .Results: The plasma level of NO in sick children was significantly higher than that in normal children (P<0.01)and the plasma level of NO in sick children with chronic tic disorders and Tourette’s Syndrome was significantly higher than that in sick children with transicent tic disorders (P<0.01). Conclusion: It is derinite that the numerical change of plasma NO happens in children with TD, and NO may be involved with pathogenesis of TD .更多还原