Objective: to determine drug resistance of pneumonia streptococcus Methods:make the medicine sensitive experiment to the pneumonia streptococcus with the methods of K-B.Results:the percentage of resistance to the erythromycin of 98 strains of pneumonia streptococcus was 40.8%,to the penicillin was 16.3%,to the vancomycin was 0%.Conclusion:Vancomycin is the best choice for pneumonia streptococcus