【摘要】 以6-氨基青霉烷酸(6-APA)为原料,在非均相反应体系中加入催化剂聚乙二醇,使氨基取代和-H的取代同时完成,制得6,6-二溴青霉烷酸.再以三氯化铝作催化剂,用工业甲醇与6,6-二溴青霉烷酸进行酯化反应.同时讨论了时间、温度、投料比和催化剂用量对酯化反应条件的影响.工业甲醇/6,6-二溴青霉烷酸(质量比)为4,三氯化铝5%(以6,6-二溴青霉烷酸的质量计),最佳反应温度为27℃,最佳反应时间为6h,产率达到96.2%.更多还原

【Abstract】 With 6-APA as raw materials, to put into catalyst gather the ethylene glycol among non equality system, it is the same finish for replacing amino and €%Z-H, make 6,6-dibromopenicillanic. by aluminiums trichloride make catalyst , there are esterification of methyl alcohol and 6,6-dibromopenicillanic. at the same time discussing,time, temperature, throw material of than and catalyst quantity react influence of terms to esterification. Industry methyl alcohol/6,6-Dibromopenicillanic acid is 4,AlCl3 5% (6,6-Dibromopenicillanic acid quality count), The best response temperature is 27 ℃, the best response time is 6h, the producing rate reaches 96.2%.更多还原