【摘要】 来曲唑是新一代强效的非甾体芳香化酶抑制剂 ,用于一线治疗晚期乳腺癌 ,并广泛用作乳腺癌的二线用药 ,疗效好 ,不良反应少 ,耐受性好 ,值得临床推广应用。本文综述了来曲唑的合成方法以及临床研究进展。更多还原

【Abstract】 Letrozole is a novel potent nonsteroidal aromatase inhibitor,which has been shown to be useful as first-line therapy in postmenopausal women with advanced breast cancer(ABC).It was well tolerated and produced potent,selective and long-lasting inhibition of aromatase.Letrozole is an effective and safe agent for treatment of ABC.The advances in the research of the synthesis and clinical studies of Letrozole were reviewed in this paper.更多还原