【摘要】 目的　研究乌斯他丁对急性重症胆管炎病人围手术期肝肾功能保护及抑制炎症反应作用。方法　以需手术治疗的重症胆管炎病人 5 8例为研究对象 ,随机分配 3 1例为试验组 ,2 7例为对照组 ,试验组连续 5天给予 2 0万u乌斯他丁静脉滴入 ,对照组仅予以常规治疗。同时术前、术后 1、3、5、7天检测血白细胞介素 -10 (IL -10 )、肝功能及肾功能指标。结果　术后第 3天试验组AST平均值低于对照组 (P <0 .0 5 ) ,术后第 3天试验组IL -10水平为 2 0 1.4± 2 6.1pg ml,对照组为 2 68± 2 8.5pg ml,差别有统计学意义 (P <0 .0 5 ) ;两组术后的血肌酐有明显差异 (P <0 .0 1)。结论　乌斯他丁对急性重症胆管炎病人围手术期的肝肾功能有保护及抑制炎症反应作用。更多还原

【Abstract】 Objective To examine the effects of perioperative administration of ulinastatin on liver and renal function,defencing inflammatory reaction in suffering from acute severe cholangitis.Methods 58 patients admitted to our department for surgical intervention on acute severe cholangitis were randomly divided into two groups:31 cases in experiment group, who were administerd ulinstatin postoperatively;27 cases in control group. Meanwhile, sera IL-l0,liver and renal function wered detected.Results The postoperative serum AST level on day 3 in experimental group is significantly lower than control group(P<0.05); The postoperative serum IL-10 level on day 3 in experimental group is significantly lower than control group(201.4±261 pg/ml VS.268±28.5 pg/ml,P<0.05); The postoperative serum creatinine level had significant difference between two groups(P<0.01).Conclusions Perioperative administration of ulinastatin has beneficial effects on liver and renal fnction,defencing inflammatory reaction in suffering from acute severe cholangitis.更多还原