【摘要】 目的　研究枢丹在不同给药时间对行腹腔镜胆囊切除术病人术后恶心呕吐 (PONV)效应的影响。方法　 75例全麻下行腹腔镜胆囊切术病人随机分为三组 ,每组 2 5例 ,第Ⅰ组 (对照组 ) ,于诱导前、术后给予生理盐水5ml;第Ⅱ组 (术前枢丹组 ) ,于麻醉诱导前给予枢丹 4mg ;第Ⅲ组 (术后枢丹组 ) ,术后给予枢丹 4mg。术后 2 4小时内恶心呕吐发作及补救止吐的需要量均被记录。结果　第Ⅱ组病人在术后 2 4小时内恶心呕吐发作率分别为 68%和2 0 %,低于第Ⅰ组的 80 %与 3 2 %,但无显著性差异 (P >0 .0 5 )。第Ⅲ组 2 4小时内恶心呕吐发作率分别为 44 %和 4%,与第Ⅰ组相比有明显降低 (P <0 .0 5 ) ,术后补救止吐剂量亦明显低于第Ⅰ组 ( 3 6%:64 %,P <0 .0 5 )。结论　预防性应用枢丹止吐的给药时间应当选择在手术结束时更多还原

【Abstract】 Objective To investigate the postoperative nausea and vomiting (PONV) effect by different injection time of ondansentron for patients undergone Cholecystectomy by laparoscopi.Methods 75 patients undergone Cholecystectomy by laparoscopi were randomly divided into 3 groups,with each group 25 cases.Patients in group Ⅰ (control group) were injected 5ml physiological saline solution before induction and after operation.Patients in group Ⅱ (preoperative ondansentron group) were injected 4mg ondansentron before anesthsia induction.Patients in group Ⅲ (postoperative ondansentron group) were injected 4mg ondansentron after opration.Data of postoperative nausea and vomiting rate and remediation antiermetic were recorded in 24 hours after operation.Results The nausea and vomitting rates in group Ⅱ were 68% and 20%,lower than group Ⅰ,but with no statistical implication (P>0.05).The nausea and vomitting rates in group Ⅲ were 44% and 4%,and was significantly lowere than group Ⅰ (P<0.05).The postoperative remediation antiermetic were also lower than group Ⅰ (36%:64%,P<0.05).Conclusions The injection time of ondansentron to prevent nausea and vomtting should be at the end of operation.更多还原