【摘要】 目的 :观察急性缺氧幼猪吸入一氧化氮 (NO)及突然停吸一氧化氮后血流动力学的动态变化。方法 :将 8头平原幼猪空运到高原 ,形成急性缺氧性肺动脉高压模型。幼猪吸入浓度为10 ppm的NO气体 ,经漂浮导管每间隔 5分钟测量一次肺动脉压、心输出量 ,经股动脉插管测股动脉压、抽血做血气分析。突然停吸NO ,重复上述测定。结果 :吸入NO气体后平均肺动脉压 (mPAP)与吸NO前比较有显著降低 (P <0 .0 1) ,股动脉血氧分压 (PaO2 )明显升高 (P <0 .0 5 )。突然停吸NO气体后 5至 10分钟mPAP迅速升高 ,并且超过吸NO前的水平 (P <0 .0 5 ) ,PaO2 迅速降至吸NO前的水平 ,15分钟后mPAP逐渐恢复到吸NO前的水平。吸NO及停NO期间 ,股动脉压、心输出量变化不明显。结论 :急性缺氧幼猪吸入低浓度一氧化氮气体后肺动脉压显著降低 ,动脉血氧分压明显升高 ;但突然停吸NO后肺动脉压迅速升高 ,且超过吸NO前的水平 ,存在反跳现象更多还原

【Abstract】 Objective:To observe the hemodynamic changes in acute hypoxia piglets which were inhaled Nitric Oxide (NO 10ppm) and suddenly released. Methods: 8 piglets were transported to high altitude areas from plain by plane and the acute pulmonary hypertension model was established. The pulmonary artery pressure (PAP) and cardiac output (CO) were measured every 5 min; the inguinal artery pressure was measured through cathete- ring. After suddenly release, the above indices were measured again. Results: After the NO inhalation, the mPAP level dropped dramatically. And after 5 to 10min ceasing the inhalation, mPAP increased rapidly and even surpassed the level before the inhalation, PaO 2 dropped rapidly. 15min later, the mPAP progressively regained the pre-inhalation level. There was little change of inguinal artery pressure and CO. Conclusions: After the inhalation of NO in acute hypoxia piglets the level of PAP decreases dramatically, PaO 2 is increased dramatically. However, after suddenly release the NO inhalation, mPAP is increased rapidly even surpassed the level before the inhalation. The rebound phenomenon exists.更多还原