【摘要】 目的　探讨百色市慢性乙肝患者重叠感染TTV状况及其基因型特点。方法　采用PCR法检测TTVDNA ,微板核酸杂交 -ELISA法检测TTV基因型。结果　本地慢性乙肝患者TTVDNA总感染率 13 2 9% ,与健康体检者比较差异有显著性 (P <0 0 5 ) ,慢性轻度乙肝感染率 6 5 2 % ,慢性中度乙肝感染率 15 2 8% ,慢性重度乙肝感染率 17 5 0 % ,三者比较差异无显著性 (P >0 0 5 ) ;2 1例TTVDNA阳性患者中Ⅰ型 15例 ,占 71 4 3% ,Ⅱ型 2例 ,占 9 5 2 % ,Ⅰ /Ⅱ混合型 4例 ,占 19 0 5 %。结论本地慢性乙肝患者重叠感染TTV较常见 ,其TTV基因型可分为Ⅰ型、Ⅱ型、Ⅰ /Ⅱ混合型 ,以Ⅰ型为主 ,TTV重叠感染可能不导致慢性乙型肝炎病人病情的加重。更多还原

【Abstract】 Objective To study the transfusion-transmitted virus(TTV) infection and genotypes of the patients with chronic hepatitis B in Baise.Methods TTVDNA and genotypes of TTV of samples were detected by PCR and mircoplate sandwich Hybridization-ELISA technique respectively.Results The total TTV infection rate of the patients with chronic hepatitis B in west Guangxi province was 13.29%,which was higher than that of the health persons(P<0.05). the TTV infection rates of the patients with chronic mild-degree hepatitis B and chronic mid-degree hepatitis B and chronic severe-degree hepatitis B were 6.52%,15.28% and 17.50%,respectively,but there was no statistical difference between there three groups. In the 21 chronic hepatitis B patients with TTVDNA electropositive, there were three genotypes of TTV, 71.43% was type Ⅰ,9.52% was typeⅡ, mixed of Ⅰ/Ⅱ was 19.05%.Conclusion The results of the study suggest that transfusion-transmitted virus superinfection is common of chronic hepatitis B in west Guangxi .Genotypes of TTV infection in chronic hepatitis B in west Guangxi were type Ⅰ,type Ⅱand typeⅠ/Ⅱ,typeⅠ. The TTV superinfection in chronic hepatitis B may not to be responsible for their clinical exacerbation.更多还原