【摘要】 目的　探讨胃、十二指肠黏膜中IL 8含量在幽门螺杆菌 (H .pylori)相关性胃十二指肠疾病中的机理。 方法　对92例H .pylori或非H .pylori感染的胃炎患儿 ,在胃镜下取胃窦及十二指肠球部黏膜活检标本 ,用ELISA法测定黏膜中IL 8的含量。结果　H .pylori阳性者胃黏膜IL 8为 (1 88± 0 0 6 ) pg/mg ,H .pylori阴性者为 (0 82± 0 0 5 )pg/mg,两者相比 P <0 0 0 1;H .pylori阳性者十二指肠黏膜IL 8为 (1 18± 0 0 6 ) pg/mg ,H .pylori阴性者为 (0 6 2± 0 0 4 )pg/mg ,两者相比 P <0 0 0 1。活动性胃炎胃黏膜IL 8为 (1 84± 0 0 7) pg/mg ,非活动性胃炎为 (0 78± 0 0 6 ) pg/mg ,两者相比 P <0 0 0 1;活动性胃炎十二指肠黏膜IL 8为 (1 19± 0 6 ) pg/mg。非活动性胃炎为 (0 6 6± 0 0 5 ) pg/mg ,两者相比 P <0 0 0 1。说明H .pylori阳性和活动性胃炎的胃黏膜及十二指肠黏膜IL 8含量均较高。结论　提示H .pylori感染时 ,IL 8在胃十二指肠黏膜局部大量中性粒细胞浸润中可能有重要作用。更多还原

【Abstract】 Objective To explore the possible role of interleukin-8(IL-8)levels in gastroduodenal mucosa in the pathogenesis of gastroduodenal diseases induced by Helicobacter pylori(H.pylori) infection.Methods Interleukin-8 content in gastroduodenal mucosa collected by gastroscopy was determined by using ELISA in 92 children with gastritis induced by either H.pylori or non- H.pylori infection.Results It showed that both of IL-8 levels in gastric mucosa and in duodenal mucosa were(1.88±0.06)pg/mg and (1.18±0.06)pg/mg in children with H.pylori infection and(0.82±0.05)pg/mg and(0.62±0.04)pg/mg in children without H.pylori infection, respectively (P<0.001;P<0.001). Furthermore, both of IL-8 levels in gastric mucosa and in duodenal mucosa were(1.84±0.07)pg/mg and(1.19±0.06)pg/mg in children with active gastritis and(0.78±0.06)pg/mg and(0.66±0.05)pg/mg in children without active gastritis, respectively (P<0.001;P<0.001). It was indicated that there is a significant increase of IL-8 level in gastorduodenal mucosa in children with either Hp infection or active gastritis.Conclusion It is suggested that IL-8 might play an important role in the pathogenesis of gastroduodenal diseases through its influence on the infiltration of a large number of neutrophils in local gastroduodenal mucosa in children with H. pylori infection.更多还原