【摘要】 目的　比较短期和长期腔内灌注吡柔比星预防浅表性膀胱癌术后复发。方法　 5 6例浅表性膀胱癌患者术后随机分为两组 ,A组 ( 2 8例 )吡柔比星 3 0mg ,每周 1次 ,共 8次 ;B组 ( 2 8例 )前 8次灌注同A组 ,以后改为每月 1次至术后 1年。随访 2年 ,观察肿瘤复发率和副反应发生情况。结果　 1年肿瘤复发率 :A组 2例( 7.2 %)、B组 1例 ( 3 .7%) ,差异无显著性 ( X2 =0 .5 76,P >0 .0 5 )。 2年肿瘤复发率 :A组 3例 ( 10 .7%)、B组 4例( 14 .3 %) ,差异亦无显著性 (X2 =0 .3 84,P >0 .0 5 )。副反应发生情况 :A组 3例 ( 10 .7%)、B组 8例 ( 2 8.6%) ,A组患者不良反应发生率低于B组 (X2 =12 .3 6,P <0 .0 1)。结论　吡柔比星短期腔内灌注预防浅表性膀胱癌术后复发疗效肯定 ,副作用小更多还原

【Abstract】 Objective To compare short term with long term intravesical instillation of pirarubicin(THP) for preventing postoperative recurrence of superficial bladder cancer.Methods Fifty six postoperative patients with superficial bladder cancer were randomized into groups A:30mg THP,once a week for 8 weeks;B:30mg THP,once a week for 8 weeks,then once a month for 1 year.A11 the patients were followed up for 2 years.The tumor recurrence rate and the side effects associated with therapy were observed.Results The tumor recurrence rate were 7.2%,3.7%(X 2=0.576,P>0.05) in group A and group B at l year,and l0.7%,14.3%(X 2=0.384,P>0.05) at 2 year after operation,respectively. Side effects of group A(10.7%)were lower than those of group B(28.6%)(X 2=12.36,P<0.01).Conclusions Short term intravesical instillation of THP for preventing postoperative recurrence of superficial bladder cancer is effective and feasible,and the side effects are mild.Bladder neoplasms;Pirarubicin;Intravesical instillation更多还原