【摘要】 目的通过研究煤矿工人血清SOD与MDA水平 ,探讨其与煤工尘肺发病和病情变化的关系。方法采用黄嘌呤氧化酶法和TBA法分别检测72名煤工尘肺患者和110名未患尘肺的接尘工人的血清SOD与MDA水平。结果尘肺组血清SOD平均水平 (105.6±24.2unit/ml)明显高于对照组 (84.9±33.1unit/ml) ,差异有显著性意义 (P<0.05) ;尘肺患者血清SOD水平随着尘肺期别的晋级而相应地升高 ,多元线性回归分析表明,尘肺患者的尘肺期别与血清SOD水平呈正相关(r=0.50,P<0.01) ;尘肺患者血清MDA平均水平与对照组的差异无显著性(P>0.05)。结论SOD与尘肺的发生发展过程有关 ,SOD水平的变化可能预示着尘肺病情的发展变化。更多还原

【Abstract】 Objective To explore the association of serum levels of SOD and MDA with the development of coal workers’pneumoconiosis(CWP).Methods Serum SOD activities and MDA levels were measured in72coal miners with CWP and110coal miners without CWP(controls)using Xanthine Oxidase and TBA method respecˉtively.Results The mean level of SOD in miners with CWP(105.6±24.2unit/ml)was significantly higher than that of the controls(84.9±33.1unit/ml).Multiple linear regression analysis revealed that levels of serum SOD were significantly correlated to CWP stages(r=0.50,P<0.01).On the other hand,no significant differences was observed in serumMDA levels between miners with or without CWP(P>0.05).Conclusion SOD may be involved in the development of CWP.The changes of serum SOD level may be a biomarker of CWP development and proˉgression.更多还原