【摘要】 建立了光在生物组织中传播的模型,利用MonteCarlo模拟技术快速计算和可移植性的优点,研究了OCT图像对比度与显微物镜数值孔径、焦距深度、时间门参数的关系,并给出它们的关系曲线。通过在所建立的模型基础上加入透镜透过率函数和光学传递函数,弥补了以往程序只能模拟光在生物组织中传播行为的缺点。该模型不仅可以分析生物组织图像与生物光学特性的关系,而且还可以指导OCT结构的完善和创新。模拟结果表明:在构建OCT时,参考臂与样品臂的这两个显微物镜的数值孔径越大,生物组织的采样深度越浅,处理信号的时间门宽度越小(但时间门宽度不能小于激光脉冲时间),混浊生物组织图像对比度越好。更多还原

【Abstract】 The relationship between OCT imaging contrast and objective numerical aperture (NA), focus depth, time gate has been studied with interrelationship established using the model established for the propagation of light in bio-tissue and the Monte Carlo simulation technology. Other simulation programs can not be used to simulate any effect of optical components, such as microscope and time gate, on OCT images. The drawback of other simulation programs to simulate the light propagation in bio-tissue only has been overcome by adding some lens permeation ratio functions and optical transmission functions to the models established. This can be used to analyze the relationship between the bio-tissue images and the bio-optical properties, and to promote the perfection and innovation of OCT configuration. Simulation results show that, while OCT is constructed, the larger the objective NAs of reference arm and sample arm are, the shallower the sample depth of bio-tissue is, and the more narrow the time gate of processing signal is, but it can not be less than laser pulse time, the better the imaging contrast of turbid tissue is.更多还原