【摘要】 PPAR是核受体超家族成员之一 ,它可以促进脂肪细胞分化 ,在脂质代谢中起着重要的作用。随着对胰岛素增敏剂尤其是噻唑烷二酮类 (TZDs)药物作用机制的深入研究 ,人们发现PPAR就是这类药物的主要作用靶点。PPAR不仅与胰岛素抵抗关系密切 ,在动脉粥样硬化、高血压、心肌肥厚和心肌炎的发生、发展及防治过程中也起着重要的作用。进一步探讨PPAR与心血管疾病的关系 ,可能为TZDs类药物治疗糖尿病心血管并发症提供新的理论基础 ,也可能为心血管药物治疗提供新的治疗靶点。更多还原

【Abstract】 Peroxisome proliferator-activated receptors (PPARs) were classified as orphan members of the nuclear receptor superfamily. It may induce adipocyte differentiation and regulate the metabolism of lipids. Recently, with further study of the mechanism of insulin sensitizer such as TZDs, it has been realized that PPARs are the main target of these drugs. PPARs not only are linked to insulin resistance, but play an important role in the development of human cardiovascular diseases such as atherosclerosis, hypertension, cardiac hypertrophy and myocarditis. This article reviews the relationship between PPARs and cardiovascular diseases, in order to provide important insight into the roles of TZDs in treating diabetic complications and find new targets of cardiovascular drugs in the future.更多还原