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依赖于DNA的RNA聚合酶Ⅲ与基因表达和基因治疗
DNA-Dependent RNA Polymerase Ⅲ, Gene Expression and Gene Therapy
【摘要】 依赖于DNA的RNA聚合酶Ⅲ (polⅢ )能催化 5SrRNA、tRNA、U6SnRNA等一些小的、稳定的RNA的合成。文章综述了依赖于DNA的RNA聚合酶Ⅲ的启动子和转录复合物 ,并介绍了RNA聚合酶Ⅲ的转录在基因表达和基因治疗 (核酶、反义核酸、RNA干扰技术等 )研究中的应用价值。
【Abstract】 DNA-dependent RNA polymerase Ⅲ synthesizes a set of small stable RNAs, such as 5S rRNA, tRNA, and U 6SnRNA etc. In this article, we review the promoters and transcription complex which are dependent on RNA polymerase Ⅲ. The application of RNA polymerase Ⅲ-catalyzed transcription in gene therapy and gene expression by the ribozyme,antisense oligonucleotides and RNA interference is also discussed.
【关键词】 RNA聚合酶Ⅲ;
转录;
基因治疗;
基因表达;
【Key words】 RNA polymerase Ⅲ; transcription; gene therapy; gene expression;
【Key words】 RNA polymerase Ⅲ; transcription; gene therapy; gene expression;
- 【文献出处】 医学分子生物学杂志 ,Foreign Medical Sciences , 编辑部邮箱 ,2004年04期
- 【分类号】R346
- 【被引频次】2
- 【下载频次】162