【摘要】 LOX-1是由内皮细胞表达的氧化性低密度脂蛋白特异性受体(OxLDL),属Ⅱ型单链跨膜蛋白,C型选择素家族。OxLDL是动脉粥样硬化形成的重要危险因子,它通过与内皮细胞表面的LOX-1结合激活内皮,影响内皮功能,损伤血管,参与动脉粥样硬化、高血压、血栓症等疾病的形成。本文综述了近年LOX-1分子生物学研究进展。更多还原

【Abstract】 Lectin-like oxidized low-density lipoprotein recaptor-1 (LOX-1) is expressed in endo-thelial cells as the major receptor for oxidized LDL. LOX-1 is a type Ⅱ membrane protein with a typical C-type lectin structure at the extracellular C-terminus. This receptor is transcriptionally upregu-lated by tumor necosis factor-alpha, angiotensin Ⅱ, shear stress and OxLDL itself. Oxidized LDL, mediated by LOX-1 , leads to endothelial activation, dysfunction and injury of endothelia, and contributes to the development of hypertension, thrombosis, atherosclerosis etc. This article reviews the advances in the research of biological function of LOX-1.更多还原