【摘要】 [目的 ]观察大鼠长期给予神光源颗粒剂是否产生毒性反应。 [方法 ]神光源颗粒剂以其提取的浸膏给药 ,小、中、大剂量组分别按 3 6 g/kg ,7 2 g/kg ,14 4 g/kg连续灌胃 6个月 ,分别相当于临床用量的 2 0倍、4 0倍、80倍。于给药 6个月时检测大鼠的体重、血液量、生化指标 ,测量心、肝、脾、肺、肾、脑、睾丸、子宫等脏器系数 ,对各脏器组织进行病理学检查。 [结果 ]神光源颗粒剂各剂量组各项指标均未见明显异常改变。 [结论 ]大鼠长期服用神光源颗粒剂安全无毒。更多还原

【Abstract】 To investigate whether long term administration of Shenguangyuan granule to rats has toxicity. The Wistar rats were divided into three groups, and the dosage of 3.6g/kg, 7.2g/kg, and 14.48g/kg were perfused respectively to the three groups for 6 months. These dosages were 20,40 and 80 times more than the clinical dosages respectively. 6 months later after discontinuation, all the body weights, hematological or biochemical indexes, both relative weight and morphologies of heart, liver, spleen, lung, kidney, brain, testis and uterus were tested.No evident abnormal change of every index was observed in every group.[Conclusion]Long term administration of Shenguangyuan granule to rats was safe.更多还原