【摘要】 目的　比较慢性病毒性乙型肝炎和其重叠戊型肝炎病毒 (HEV)感染的临床特点 ,乙型肝炎病毒 (HBV)复制指标 ,以及肝功能方面是否存在差异 ;了解HEV感染对HBV复制的影响。方法　应用酶联免疫吸附试验和聚合酶链反应分别检测HBV组和HBV +HEV组中的乙型肝炎两对半 ,抗 HBcIgG ,抗 HBcIgM ,HBVDNA ,抗 HEVIgM。 结果　重叠HEV感染较单纯HBV感染病情重 ,肝功能损害明显 ;10 0例HBV重叠HEV感染者的HBVDNA和乙型肝炎e抗原 (HBeAg)阳性率分别为 36 %和 2 3% ,10 0例单纯HBV感染者的HBVDNA和HBeAg阳性率分别为 86 %和 6 0 %。结论　重叠HEV感染可加重HBV感染者的病情 ,并能抑制HBV复制。更多还原

【Abstract】 Objective To expore the influence of hepatitis E virus (HEV) infection on the replication of hepatitis B virus (HBV) by observing clinical features, replication markers and liver function of HBV/HEV coinfection patients. Methods HBsAg, HBsAb, HBeAg, HBeAb, HBcAb, anti-HBc-IgG, anti-HBc-IgM, HBVDNA and anti-HEV-IgM were detected respectively by enzyme linked immunosorbent assay (ELISA) and polymerase chain reaction (PCR) in HBV/HEV coinfected patients and those only infected with HBV. Results The HBV/HEV coinfected patients were more severe than only HBV infected patients. The positive rates of HBVDNA and HBeAg were 36% and 23% respectively in the HBV/HEV coinfected group; 86% and 60% respectively in those only infected with HBV. Conclusion The infection of HEV may inhibit the replication of the HBV.更多还原