【摘要】 目的 :探讨酒精对慢性丙型肝炎患者免疫功能的影响。方法 :用高效液相层析 (HPLC)法检测血清新喋呤水平 ,用RT -PCR定量检测血清中HCVRNA ,嗜酒者和非嗜酒者均接受干扰素治疗结果 :嗜酒者新喋吟的水平明显低于非嗜酒者组 ,嗜酒者组血清中HCVRNA明显高于非嗜酒者组 ,干扰素治疗后非嗜酒者丙氨酸氨基转移酶下降明显 ,而嗜酒者下降不明显。结论 :酒精显著降低慢性丙型肝炎患者的免疫功能更多还原

【Abstract】 Objective:To investigate the effect of alcohol upon the immunologic function of the patients with chronic hepatitis.Method:The serum neopterin levels and HCV RNA were determined by HPLC and RT-PCR,respectively.Both alcoholist and none alcoholist were treaed with IRN.Results:The serum neopterin levels of alcoholists were higher than those of none alcoholists.After IFN therapy,Alanine aminotransferase decreased significantly in alcoholist group,but not significantly in none alcoholist group.Conclusions:Alcohol depresses immunologic function of chronic hepatitis C patients.更多还原