【摘要】 目的:观察肉毒杆菌毒素A(BTA)治疗先天性眼球震颤(CN)的效果。方法:先天性眼球震颤患者22例,男17例,女5例。用眼震图(ENG)检查BTA注射相应眼外肌前与注射后1wk,1,3,6mo的近、远距离眼震,视力,3级视功能情况,各组进行统计学处理,并比较统计学差异。结果:各组注药前后视力改变无统计学差异(P>0.05)。注药后1mo与注药前相比,远近距离原眼位的各眼震参数降低均有明显统计学差异(P<0.05);注药后3,6mo与注药前相比近、远距离原眼位振幅降低有明显统计学差异(P<0.05);最小震强位置注药后1wk,1,3,6mo与注药前相比虽无明显差异,但从频数分布图中可见最小震强出现的位置有向原眼位集中的趋势。注药后3,6mo3级视功能与注药前相比仅融合范围扩大有显著差异(P<0.05)。结论:该方法治疗先天性眼球震颤可使近、远距离原眼位眼震有所减轻,视力、代偿头位及3级视功能有所改善。注药后1mo疗效最显著,6mo后疗效下降。该方法治疗先天性眼球震颤有明显效果。更多还原

【Abstract】 AIM: To investigate the effect of botulin A (BTA) on patients with congenital nystagmus (CN).· METHODS: Twenty-two CN patients (44 eyes, including 5 females and 17 males) were treated with BTA of the lowest effective dosage injected directly into the patients’ correlative extrocular muscles. The changes in ocular nystagmus were measured by electronystagmography (ENG) before the BTA injection and one week, one month, three months, and half a year afterwards. Meanwhile the changes in visual acuity and three-degree visual function were also measured.· RESULTS: Visual acuity at different time before and after the injection did not show significant changes (P>0.05). Compared with the nystagmus data in the near- and far-distance primary positions before the injection, they all decreased significantly 1 month after the injection (P<0.05). Compared with the nystagmus amplitude in the near- and far-distance primary positions before the injection, it decreased significantly three months and half a year after injection (P<0.05). The lowest intensity position, which reflected the changes of compensatory head postures, did not change obviously after injection, although it showed the tendency of becoming closer to the primary eye position. As for three-degree binocular vision, the fusion range amplified significantly 3 and 6 months after injection (P<0.05).· CONCLUSION: This treatment of CN is proved effective in reducing nystagmus at the primary eye position, improving the compensatory head postures, visual acuity and three-degree binocular vision to some extent. The most effective period occurs at one month after injection. The effect begins to reduce six months after the injection when compared with that at one month.·更多还原