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含核酸碱基混合脂质体的制备与膜内分子识别

Preparation of Phosphatidylcholine/Cationic Amphiphilic Coliposomes and Molecular Recognition in the Bilayer Membranes

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【作者】 宋立明凌星李国文

【Author】 SONG Li-Ming, LING Xing, LI Guo-Wen * (Key Laboratory for Supramolecular Structure and Materials of Ministry of Education, Jilin University, Changchun 130023, China)

【机构】 吉林大学超分子结构与材料教育部重点实验室吉林大学超分子结构与材料教育部重点实验室 长春130023长春130023长春130023

【Abstract】 An amphiphile, 9-octanyl adenine trimethylammonium bromide(OATMAB amphiphile 3), was synthesized as the receptor. The coliposomes were prepared from phosphatidylcholine and 9-octyl adenine trimethylammonium bromide by sonication of CHCl 3-cast films of amphiphiles mixtures [n(PC)∶ n(MOATMAB)=10∶1] in doubly distilled water with a bath-type sonicator at 80 W for 3 h. As thymine was added into PC/MAOTMAB coliposomal solution, the absorbability of thymine at 263 nm decreased slowly with time change from 0 to 72 h. The UV-Vis spectroscopic behavior of the thymine in PC/OATMAB/thymine coliposomes(molar ratio=10∶1∶1) was slowly decreaced with the increase of time. The onset of a hypochromic effect can be ascribed to adenine-thymine interaction. The absorption band levels off at 45.4% of its initial value and stabilizes after several weeks.

【基金】 国家自然科学基金 (批准号 :2 0 2 740 15 );吉林大学创新基金资助
  • 【文献出处】 高等学校化学学报 ,Chemical Research In Chinese Universities , 编辑部邮箱 ,2004年12期
  • 【分类号】O629
  • 【被引频次】2
  • 【下载频次】136
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