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小分子玉米肽Leu-Asp-Tyr-Glu保护线粒体抗氧化损伤的研究

Protection of Small Molecule Corn Peptide Leu-Asp-Tyr-Glu from Mitochondria Against Oxidative Damage

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【Author】 XU Li\+1,LI Xiang-Lu\+1,HUANG Yi-Bing\+1,WU Xiao-Xia\+1,HOU Rui-Zhen\+1, WANG Hua\+2,WANG Na\+1,ZHANG Xue-Zhong\+\{1*\} [WT5”BX](1. Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education,Jilin University,Changchun 130023;2. China-Japan Union Hospital of Jilin University,Changchun 130031,China) [WT5HZ]

【机构】吉林大学分子酶学工程教育部重点实验室；吉林大学中日联谊医院；吉林大学分子酶学工程教育部重点实验室长春130023；长春130023；长春130031；长春130023；

【Abstract】 A small molecule peptide Leu-Asp-Tyr-Glu(LDYE) prepared from the enzymatic hydrolysate of zein was tested for its anti-oxidative activities. The effects of LDYE on the turgidity of mitochondria,the fluidity of membrane,the activity of cytochrome C oxidase and ATPase at subcellular level were investigated by using H\-2O\-2/Fe\+\{2+\} -induced mitochondria damage model system. It was found that the small peptide exhibited an obvious ability of removing free radicals and protecting the mitochondria from damage by oxidation. [WT5HZ]更多还原

【关键词】玉米肽；线粒体；抗氧化活性；
【Key words】 Corn peptide； Mitochondria； Anti-oxidation activity；

【基金】国家“十五”科技攻关计划项目 (批准号 :2 0 0 1BA747C)资助

【文献出处】高等学校化学学报 ,Chemical Research In Chinese Universities , 编辑部邮箱 ,2004年06期

【分类号】Q25
【被引频次】43
【下载频次】395

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