【摘要】 目的　探讨分析肝局灶性结节性增生 (FNH)的发病机制、病理特点、诊断鉴别诊断和治疗。方法　回顾性分析1 995 - 2 0 0 3年经手术和病理学证实的 6例肝局灶性结节性增生 ,并结合以往文献报道进行探讨研究。结果　 6例 FNH均无服用类固醇激史及避孕药史 ,男性多于女性 ,AFP均阴性 ,4例有乙肝感染证据 ,5例有典型的病理改变 ,1例伴有血管瘤样病变 ,1例在肝硬化基础上发病 ,6例均行手术切除 ,无术后并发症及死亡。结论　 FNH的发病机制不详 ,联合应用影像学检查可提高其诊断水平 ,但 FNH和恶性肿瘤的关系不明确 ,误诊率较高 ,应积极手术治疗更多还原

【Abstract】 Objective To explore and investigate the pathogenesis,pathologic characters,diagnosis,differential diagnosis and treatment of hepatic focal nodular hperplasia(FNH).Methods To analyse retrospectively 6 cases with FNH who admitted to our department and underwent surgery between 1995 and 2002.All of them were proved by pathology,and also we reviewed the recent literature.Results All 6 cases did not have a history of using steroid hormone and oral contraceptive.The amount of male was more than female’s.AFP was negative in all patients.4 cases had an evidence of hepatitis B.The typical pathologic feature was presented in 83%(5/6) of patients.One case was accompanied by the angioma,another one was liver cirrhosis.Because the preoperative diagnosis was equivocal,all patients underwent focus resection.There was not mortality and severe complication.Conclusion The pathogenesis of FNH was unclear.The level of diagnosis can be increased through the combination of several imaging modalities.However,the relationship between FNH and malignant tumor remains unclear and the rate of misdiagnosis is higher.Surgcial resection should be actively performed.更多还原