【摘要】 选择N?异丙基丙烯酰胺(N-isopropylacrylamide,NIPAM)为单体,N,N’?亚甲基双丙烯酰胺(Methylenebisacrylamide,MBA)为交联剂,用辐射化学方法合成了具有温敏的PNIPAM包覆Fe3O4磁导向纳米粒子。研究了NIPAM单体浓度、交联剂MBA用量、不同光照时间及温度对核壳结构磁性纳米粒子粒径的影响,发现在一定范围内随单体NIPAM浓度的增加、交联剂MBA浓度的减小、光照时间的增加,聚NIPAM包覆Fe3O4核壳结构纳米粒子的粒径增大。在25—39℃温度范围内PNIPAM包覆Fe3O4核壳结构纳米粒子具有最低临界溶解温度特性(Lowercriticalsolutiontemperature,LCST)。以SEM和动态激光光散射仪(PCS)对该核壳结构纳米粒子粒径进行测定,表明辐射化学方法合成的核壳结构纳米粒子比较均匀。更多还原

【Abstract】 Fe3O4 magnetic nanoparticles were modified with poly (N?isopropylacrylamide) under UV irradiation. It has been found that the diameter with narrow distribution of the modified Fe3O4 nanoparticles measured by PCS in aqueous solution can be controlled easily by changing concentration of monomer NIPAM and cross?linker MBA, temperature and time. It has been also shown that the modified Fe3O4 nanoparticles are featured by lower critical solution temperature (LCST) while the temperature varies from 25℃ to 39℃. This may suggest promising application of the nanopartucles in medicine.更多还原