【摘要】 过硫酸钠在碱性条件下能氧化鲁米诺产生微弱化学发光 ,硝苯地平能大大增强此发光。基于此 ,建立起了一种直接测定硝苯地平的流动注射化学发光方法。该方法线性范围为 0 .0 5～ 5 .0mg/L ;检出限为0 0 1 7mg/L ;相对标准偏差为 2 .8% (硝苯地平 0 .5mg/L ,n =1 1 )。利用该方法测定了硝苯地平片剂含量 ,结果令人满意更多还原

【Abstract】 A novel chemiluminescence (CL) system coupled with flow injection technique was developed for determination of nifedipine. It was found that the luminol could react with persulfate in sodium hydroxide media, producing a weak chemiluminescence, which could be sensitized intensively by nifedipine. The sensitized chemiluminescence intensity was a linear function of nifedipine concentration. Under the optimal conditions (luminol concentration: 1.0×10 -4 mol/L, persulfate concentration: 1.0×10 -3 mol/L, sodium hydroxide concentration: 0.2 mol/L), the proposed method had a linear range of 0.05～5.0 mg/L with a regression equation Δ I= 330.2C+52.83 (C : nifedipine concentration, mg/L, r =0.9991). The detection limit was 0.017 mg/L with a RSD of 2.8% (nifedipine concentration: 0.5mg/L, n =11). This method was sensitive, simple, rapid, and was successfully applied to the determination of nifedipine in tablets.更多还原