【摘要】 目的 :探讨活体1 HMRS对高级别星形细胞瘤和单发转移瘤的鉴别诊断价值。方法 :搜集行1 HMRS检查的高级别星形细胞瘤 2 5例 (包括间变型星形细胞瘤 11例 ,胶质母细胞瘤 14例 ) ,单发转移瘤 10例。比较两组肿瘤强化区及肿瘤周围区之间Cho/Cr、NAA/Cr及Lac/Cr值。结果 :2 5例高级别星形细胞瘤与 10例单发转移瘤强化区的Cho/Cr分别为 5 .770 0± 1.82 12及 4.45 0 0± 2 .42 5 0 ,NAA/Cr分别为 0 .9476± 0 .5 0 2 6及 1.185 0± 0 .5 63 7,Lac/Cr分别为 2 .4684± 1.710 5及 3 .2 110± 2 .70 77,两组之间差异均无显著性意义 (P >0 .0 5 )。而肿瘤瘤周区的Cho/Cr分别为 2 .3 3 0 0± 1.2 10 0及1.0 75 0± 0 .2 5 41,差异具有显著性意义 (P <0 .0 0 1) ;NAA/Cr及Lac/Cr之间差异无显著性意义。结论 :应用1 HMRS检测肿瘤周围区代谢水平的高低可作为鉴别高级别星形细胞瘤和单发转移瘤的补充手段更多还原

【Abstract】 Objective:To evaluate the in vivo proton MR spectroscopy in differential diagnosis between high grade astrocytomas and solitary metastases.Methods:25 cases of high grade astrocytomas, including 11 anaplastic astrocytomas and 14 multiform glioblastomas, and 10 solitary metastases were collected. All of them underwent MR spectroscopy. The Cho/Cr、NAA/Cr and Lac/Cr of enhancing region and peritumoral region were compared respectively.Results:The Cho/Cr of 25 high grade astrocytomas and 10 metastases was 5.7700±1.8212 and 4.4500±2.4250,respectively; the NAA/Cr was 0.9476± 0.5026 and 1.1850±0.5637 respectively; the Lac/Cr was 2.4684±1.7105 and 3.2110±2.7077 respectively. But there was no significant difference for all ratios mentioned above between the two groups( P >0.05).The Cho/Cr in peritumoral regions of the two groups was 2.3300±1.2100 and 1.0750±0.2541 respectively, and there was significant difference( P <0.001),but the NAA/Cr and Lac/Cr of the two groups had no significant difference.Conclusion: 1H MRS can be used as a supplementary method to differentiate high grade astrocytomas from solitary metastases, based on the different metabolic levels of peritumoral region.更多还原