【摘要】 目的 :通过测定血清S - 10 0B蛋白浓度 ,探讨其在颅脑损伤诊断分型中的意义。方法 :80例颅脑损伤患者 ,根据格拉斯哥昏迷评分 (GCS评分 )分为轻型、中型、重型三组 ,伤后早期 (<6h)用酶联免疫吸附法测定血清S - 10 0B蛋白浓度 ,并动态检测 (3～ 7)d。结果 :各组血清S - 10 0B蛋白平均浓度 ,轻型组 :(0 35± 0 13)μg/L ;中型组 :(0 77± 0 2 0 ) μg/L ;重型组 :(1 12± 0 30 ) μg/L。三组比较得出P <0 0 0 5 ,S - 10 0B蛋白含量与GCS评分成负相关。结论 :血清S - 10 0B蛋白浓度是判断颅脑损伤诊断分型较为理想的生物学指标。更多还原

【Abstract】 Objective To investigate the clinical significance of determination of serum S-100B protein levels in the grading of brain injury. Methods Eighty patients with brain injury were classified in to three grades according to the Glascow score: 13～15, minor grade n=30; 9～12, moderate, n=25; 3～8, severe n=25. Serum S-100B protein levels were measured with ELISA in these patients 6h after the injury and daily thereafter for 3～7 days. Results The mean concentrations of serum S-100B protein in these patients were as followings; minor grade, 0.35±0.13μg/L; moderate grade, 0.77±0.20μg/L; severe grade 1.12±0.30μg/L(differences among them being significant, P<0.005). The S-100B protein levels were negatively correlated with the Glascow score. Conclusion Serum concentrations of S-100B protein is an ideal screening bio-marker for the severity of brain injury.更多还原