【摘要】 目的 :探讨窒息新生儿血中皮质醇、胰岛素的变化及临床意义。方法 :采用化学发光免疫法 (CLIA)和放射免疫分析测定 38例窒息新生儿 (其中轻度窒息 2 0例、重度窒息 1 8例 )和 30例无窒息史及无内分泌疾病的新生儿上述 2种激素水平 ,并进行相关分析。结果 :①轻度窒息组血清胰岛素与对照组比较有显著性差异(p <0 0 1 ) ,而皮质醇则有非常显著性差异 (p <0 0 0 1 ) ;②重度窒息组血中无论是胰岛素还是皮质醇与对照组比较均有非常显著性差异 (p <0 0 0 1 )。 结论 :窒息新生儿由于缺氧而引起激素水平的改变 ,提示临床医生在抢救该类患儿时应密切监测皮质醇、胰岛素 ,应用糖皮质激素治疗时应慎重 ,严格掌握适应症和剂量更多还原

【Abstract】 Objective To investigate the clinical significance of the changes of serum cortisol and insulin levels in neonates with asphyxia. Methods Serum cortisol levels were determined with CLIA and serum insulin levels with RIA in 38 neonates with asphyxia (mild degree 20, advanced 18) and 30 controls. Results ① In mild cases, serum insulin levels were significantly higher than those in controls ( p <0 01) and serum cortisol levels were very significantly higher ( p <0 001). ② In advanced cases, both serum insulin and cortisol levels wre very significantly higher than those in the controls ( p <0 001). Conclusion Hypoxia in the neonates with asphyxia is a very severe stress and will induce hypersecretion of cortisol and hyperglycemia which is detrimental to the patients. However hypersecretion of insulin will result in hypoglycemia, which is also very damaging. Physicians in charge should be aware of these possibilities and deal with them appropriately.更多还原