【摘要】 目的 探讨急性脑梗死患者血小板活性的改变。方法 选用26例急性脑梗死患者(70.5±9.2岁,男/女:16/10例),在发病第一周内留取血样,其中10例患者第二周再次取血;20例健康体检者(68.3±11.2岁,男/女:11/9)为正常对照组。使用全血流式细胞仪法检测血小板表面CD62p分子阳性的血小板百分数。结果CD62p~+血小板百分数在急性脑梗死发病第一、二周,以及正常对照组分别为4.46±2.51、2.35±1.52和0.73±0.47,t检验示脑梗死组较对照组高(第一周;t=7.42,P=0.00;第二周:t=3.29,P=0.00;10例患者发病第一周较第二周CD62p~+血小板百分数明显高(4.93±2.81和2.35±1.52％,t=3.54,P=0.06);第一周CD62p~+血小板百分数与年龄、性别、高血压、糖尿病和吸烟的多元回归分析,未发现与血小板激活显著相关的因素。结论 急性脑梗死发病初期血小板活性最高,然后急剧下降,但仍较正常明显增高。更多还原

【Abstract】 Objective To investigate the activity of platelets in acute ischemic stroke patients. Methods 26 patientswith acute ischemic stroke were enrolled in this trial. All the blood samples were collected in the first week after stroke onset.10 cases were recollected in the second week. The percentages of CD62p~+ platelets were determined with flow cytometry.Results The percentages of CD62p~+ platelets among acutestroke patients in the first and second week and the control were 4. 46±2. 51, 2. 35±1. 52 and 0.73±0. 47, respectively. T tests showed the percentages of CD62p~+ of both groups in the first andsecond week were significantly higher than that of the control group (First week: t= 7. 42, P= 0. 00. Second week: t= 3. 29,P = 0. 00). To the 10 reexamined cases, the percentages of CD62p~+ of the first week were also prominently more than that ofthe second week (4. 93±2. 81% and 2. 35±1. 52%, respectively. t= 3. 54, P= 0. 06). Multiple parametet regression analysisbetween CD62p~+ percentage and age, sex, hypertension, diabetes mellitus and smoking did not find any potential risk factors.Conclusion The activity of platelets is the highest in the early days of acute stroke and decreases rapidly but still higher thannormal.更多还原