【摘要】 目的研究阿霉素碘油乳(AD-E)经肝动脉栓塞后的靶向特征及体内药代动力学过程。方法经犬肝动脉注入AD-E,用高效液相色谱(HPLC)荧光检测外周静脉血和肝栓塞部位组织中阿霉素药物浓度,并与阿霉素溶液给药组对照。结果AD-E组外周静脉阿霉素血药浓度显著低于阿霉素组,其T1/2 β为阿霉素组的1.51倍。给药后10、24和48h,AD-E组肝组织中阿霉素浓度分别为阿霉素组的5.42、3.33、和2.38倍。结论AD-E肝动脉栓塞给药明显改变阿霉素犬体内的药代动力学过程及肝组织靶向定位特征。更多还原

【Abstract】 Objective To study the phamacokinetics and targeting characteristics of adriamyin in dogs following embolization of hepatic artery with adriamyin-lipiodol emulsion (AD-E). Methods After injection of adriamycin solution and the emulsion, respectively, into the hepatic artery via a femoral artery of the dogs, the concentration of adriamycin in the peripheral venous blood and hepatic tissue were determined by high-performance liquid chromatography. Results The concentration of adriamycin in peripheral venous blood was significantly lowered after AD-E embolization in comparison with that after adriamycin solution injection. Adriamycin concentration in the hepatic tissue at 10, 24, and 48 h after AD-E embolization was 5.42, 3.33 and 2.38 times that of adrimycin solution group, respectively. Conclusion Compared to adriamycin solution, AD-E as an embolic agent can significantly alter the serum pharmacokinetics and liver targeting characteristics of adriamycin.更多还原