【摘要】 抗菌多肽广泛分布于动物、植物 ,用于抵御细菌、真菌、病毒和原虫 ,在进化上是一类非常古老而有效的天然防御物质。两栖动物的后天获得性免疫系统与哺乳动物相比极为脆弱 ,它们在长期的进化历程中演化形成了一套非常有效的抵御微生物侵袭的防御系统 ,这套系统主要就是其裸露皮肤表面的抗菌多肽 (又称初级免疫或者先天免疫系统 )。本文结合本实验室近年的研究工作 ,对两栖类皮肤抗菌多肽的结构、功能及应用作一简要综述。更多还原

【Abstract】 Antimicrobial peptides are distributed in animals and plants,and acted as the first defensive line against microorganisms.Compared with mammals,the acquired immune system in amphibians is very fragile.The innate system is mainly composed of antimicrobial peptides in amphibian skins that act as very important defensive function against the invasiveness of microorganisms including bacteria,fungi,virus and protozoa.A mini-review about the structure,function and application of amphibian antimicrobial peptides is reported in this paper.更多还原