【摘要】 目的:观察听觉诱发电位指数全麻诱导期间的变化,评价其在临床上监测麻醉深度的价值。方法:选择胸腹部手术且听力正常的病人36例（ASAⅠ～Ⅱ）,分别采用Mid-Fen-Ro（Ⅰ组）和Mid-Fen-Pro-Ro（Ⅱ组）顺序诱导。监测记录诱导前基础值（T₀）,静注Mid后1min（T₁）、静注Fen后1min（T₂）、Ⅱ组静注Pro后1min（T₃）、静注Ro后1minⅠ组（T₃）和Ⅱ组（T₄）、插管后1minⅠ组（T₄）和Ⅱ组（T₅）;上述各点的AEPI、MAP和HR。结果:两组病人全麻诱导气管插管前均能达到满意的麻醉深度,但Ⅰ组气管插管后MAP和HR均较T₀和插管前明显升高（P<0.01）,插管前后比较AAI明显升高,较T₃值有显著差异（P<0.001）Ⅱ组气管插管后（T₅）MAP和HR与T₀比较无差异,较T₄也升高,但不如Ⅰ组明显;AAI也较T₄明显升高,但仍处于临床麻醉状态。结论:麻醉诱导期间AAI能准确地反映临床镇静麻醉深度;咪达唑仑和异丙酚联合使用能平稳地诱导麻醉且用药量小。更多还原

【Abstract】 Objective: To observe the changes of auditory evoked potentials index（AEPI） during induction and trachealintubation and evaluate its value on anasthesia depth monitoring. Methods: Thirty--six ASAⅠ--Ⅱ patients scheduled for elec-tive surgery under general anesthesia. Patients wh psychoneural diseases or hearing disturbances were excluded. Anesthesiawere induced respectively with midzolam 0.2mg/kg, fentanyl 3μg/kg, rocuronium 0.6mg/kg and midzolam 0.02mg/kg, fentanyl3μg/kg,propofol 0.8mg/kg, meuronium 0.6mg/kg given Ⅳ in sequence with an interal of 1 mintue between two injections andmaintained with enfluren inhalation. The depth of anesthesia was monitored by AAI. These parameters were monitored continu-ously and recorded before induction （T₀）, at 1 minute after each injection and 1 minute after intubation. Results: All patientsrecieved satisfactory depth of anesthesia before intubation. But compared with basic value （T₀）, the value of MAP and HR afterintubation （T₄） increased significantly in group Ⅰ, AAI increased significantly compared with that of T₃ （P<0.001）. In group Ⅱ,MAP and HR after intubation （T₅） have no significant difference with basic value （T₀） （P> 0.05）, MAP, HR and AAI have signif-icant difference with that of T₄ （P<0.05）, but patients were in clinical anesthetized state. Conclusions: AAI can predict fairlywell the level of sedation during induction and tracheal intubation. Induction of anesthesia with intravenous midazolam--fen-tanyl--propofol is smooth and effective with little circulatory disturbance.更多还原