【摘要】 目的　探讨肺心病患者的血栓前状态 ,观察并分析低分子肝素抗凝干预的疗效。方法　将 5 4例肺心病患者分为低分子肝素治疗组和常规治疗组各 2 7例 ,分别检测治疗前后血浆血管性假血友病因子 (VWF)、血浆凝血酶片段 1+ 2 (F1+ 2 )、纤维蛋白原 (Fg)、血小板颗粒膜蛋白 (GMP -14 0 )和D一二聚体 (DD)。结果　肺心病患者VWF、F1+ 2 、Fg、GMP -14 0、DD血浆浓度显著高于对照组 ;肺心病治疗组经LMWH治疗后上述各凝血分子标记物及PaCO2 明显降低 ,而PaO2 显著增高 ,常规组虽血气指标略有改善 ,但凝血分子标记物未见改善。结论　尽早检测肺心病血栓前状态 ,及时给予低分子肝素抗凝干预 ,有望从根本上改善肺心病急性加重期患者的不良预后。更多还原

【Abstract】 Objective To explore pre-thrombosis state in patients with cor pulmonale and the efficacy of anticoagulant treatment with low molecular heparin(LME). Methods 54 patients with cor pulmonale were divided into LMH treatment group and routine treatment group, each group containing 27 patients. The concentrations of Von Willlebrand factor (VWF),prethrombin F 1+2 fragment(F 1+2 ),Fibrinogen(Fg),granule membrane protein(GMP-140)and D-dimer fragment(DD)were measured before and after treatment. Results The concentrations of WF,F 1+2 ,Fg,GMP-140 and DD in the patients with cor pulmonale were significantly higher than those in the controls. In LMH treatment group, the above indices and PaCO 2 markedly decreased and PaO 2 obviously increased, while in routine treatment group, PaCO 2 and PaO 2 slightly improved, and no change was observed in coagulation indices. Conclusion Early detection and diagnosis of pre-thrombosis state in patients with cor pulmonale and immediate treatment with LMH can be beneficial to the prognosis of these patients in acute stage.更多还原