【摘要】 目的　探讨普伐他汀 (pravastatin ,PT)对同型半胱氨酸 (homocysteine ,Hcy)损伤家兔离体胸主动脉内皮依赖性舒张功能的影响。方法　采用离体胸主动脉环方法检测乙酰胆碱诱导的内皮依赖性舒张反应来评价Hcy对血管内皮功能的损害和PT的保护作用。结果　分别用 1～ 10mmol/LHcy孵育血管环 3 0min ,呈浓度依赖性地抑制乙酰胆碱诱导的内皮依赖性舒张反应。用 0 3～ 3mmol/LPT分别预孵育血管环 15min ,再与 3mmol/LHcy共孵育 3 0min ,则显著改善Hcy所致的血管舒张功能的损害 ,并有剂量依赖性。结论　这些结果提示 ,PT对Hcy所致血管内皮依赖性舒张功能的损伤具有明显的保护作用。更多还原

【Abstract】 Objective To explore whether pravastatin protects endothelium against the damage induced by homocysteine (Hcy) in isolated rabbit aorta. Methods Endothelium-dependent relaxation responses to acetylcholine (ACh) of thoracic aortic rings were measured by isometric tension recording before and after aortic rings exposed to Hcy in the absence or presence of pravastatin (PT) to estimate the injury effect of Hcy and the protective effect of pravatatin on rabbit aortic endothelium, respectively. Results Incubation of aortic rings with 1～10mmol/L Hcy for 30min significantly inhibited endothelium-dependent relaxation response to ACh of aortic rings in a concentration-dependent manner. Pre-incubation of aortic rings with 0.3～3mmol/L PT for 15min and co-incubation of aortic rings with 3mmol/L Hcy for another 30min markedly attenuated the inhibition of endothelium-dependent relaxation induced by Hcy in a concentration-dependent manner. Conclusion Pravastatin can improve the impairment of endothelium-dependent relaxation induced by Hcy in isolated rabbit aorta.更多还原