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原发性肺部恶性肿瘤与COPD患者外周血淋巴细胞亚群和NK细胞水平测定的临床探讨

A Clinical Study on the Level of Lymphocyte Sub-population and NK Cell in Patients with Primary Lung Malignant Tumor and COPD Patients

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【作者】 夏瑾玮王蓓芸刘一雯梁瑞廉

【Author】 XIA Jin-wei,WANG Bei-yun, LIU Yi-wen, et al. Department of Geriatrics, The Sixth People’s Hospital of Shanghai City, Shanghai 200233, China

【机构】 上海市第六人民医院老年科上海市第六人民医院中心实验室上海市第六人民医院老年科 上海200233上海200233上海200233

【摘要】 目的 探讨原发性肺部恶性肿瘤与慢性阻塞性肺部疾病 (COPD)患者外周血淋巴细胞亚群及NK细胞水平测定的临床价值。方法 应用单克隆抗体 -碱性磷酸酶抗碱性磷酸酶法 (APAAP法 )测定 60例COPD病人 ,5 0例原发性肺部恶性肿瘤病人和 40例正常对照组CD3 + ,CD4+ ,CD8+ ,CD19+ 及NK细胞的百分数 ,计算CD4+ /CD8+ 比值。结果 原发性肺部恶性肿瘤组、COPD组的CD3 + ,CD4+ ,CD4+ /CD8+ ,CD19+ 明显降低 ,而CD8明显增高 ,与对照组比较均有显著差异 (P <0 0 1) ;原发性肺部恶性肿瘤组的NK细胞的百分数降低 ,与对照组比较有显著差异 (P <0 0 1) ,COPD组NK表达与对照组比较无显著差异 (P >0 0 5 )。原发性肺部恶性肿瘤组与COPD组的CD3 + ,CD4+ ,CD8+ 均无明显差异 (P >0 0 5 ) ,而NK ,CD19+ 有差异 (P <0 0 1)。结论 原发性肺部恶性肿瘤组和COPD组存在细胞免疫功能紊乱和失调 ,临床上应不失时机的应用免疫调节剂

【Abstract】 Objective To explore the clinical value of lymphocyte sub-population and NK levels in patients with primary lung malignant tumor and patients with chronic obstructive pulmonary disease (COPD). Methods The percentage of CD3 +,CD4 +, CD8 +, CD19 + and NK cells were measured in 60 COPD patients and 50 primary lung malignant tumor patients and 40 normal control subjects using alkaline phosphatase antialkaline phosphatase (APAAP) assay, and CD4 +/CD8 + ratio was calculated. Results The levels of CD3 +,CD4 +,CD4 +/CD8 + and CD19 + cells were significantly lower in the patients with primary lung malignant tumor or COPD than those in the normal control subjects, which CD8 level was significantly higher (P<0.01). The percentage of NK cells in the patients with primary lung malignant tumor was significantly lower than that in control subjects(P<0.01), which the percentage of NK cells in COPD patients had no statistic difference compared with the control subjects(P>0.05). No difference in the levels of CD3 +, CD4 + and CD8 + cells was found between the primary lung malignant tumor and COPD patients, but NK and CD19 + cells levels had significant difference(P<0.01). Conclusion The immunological function was markedly abnormal in primary lung malignant tumor and COPD patients. It is necessary to use immunity modulator for treating these patients in time.

  • 【文献出处】 中国医师杂志 ,Journal of Chinese Physician , 编辑部邮箱 ,2004年08期
  • 【分类号】R734.2
  • 【被引频次】8
  • 【下载频次】58
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