【摘要】 目的　探讨糖尿病合并高血压对糖代谢 ,脂代谢和肾功能的影响。方法　对住院的糖尿病患者 3 10例进行高血压组(n =15 0 )和非高血压组 (n =160 )划分 ,采集血标本并测定血糖 ,胰岛素 ,C肽 ,血脂 ,血肌酐 ,尿微量白蛋白等项目 ,进行统计分析处理。结果　高血压组较非高血压组的空腹和餐后血糖明显升高 (P <0 0 5 ,P <0 0 1) ,餐后胰岛素和空腹C肽明显低下 (均为P<0 0 1) ;除HDL外 ,脂代谢各项数据均显著升高 ;尿微量白蛋白排量分别是 ( 3 1 6± 3 3 3 ) μg/min和 ( 2 2 5± 18 5 ) μg/min ,有显著性差异 (P <0 0 1)。结论　在糖尿病和高血压的双重损害作用下 ,糖、脂代谢异常和肾功能损害明显加重更多还原

【Abstract】 Objective To investigate the influence of the diabetes with hypertension on glucose and lipid metabolism as well as renal function. Methods 310 diabetic inpatients were divided into hypertension group (n=150) and non-hypertension group (n=160). The levels of plasma glucose, insulin, C-peptide, lipid and creatine, as well as microalbuminuria were measured. The results were statistically analyzed. Results Compared with non-hypertension group, in hypertension group the plasma levels of fasting glucose and postprandial glucose significantly increased (P<0 05,P<0 01), the plasma levles of postprandial insulin and fasting C-peptide significantly decreased (P<0 01), and the plasma lipids levels (TG, T-ch, LDL, Apo-A and Apo-B) significantly increased except HDL. Microalbuminuria level in hypertension group (31 6±33 3μg/min) was significantly higher than that in non-hypertension group (22 5±18 5μg/min) (P<0 01). Conclusion Hyperglycemia and hypertension caused more disorder in the glucose and lipid metabolism and renal function became worse in the diabetic patients with hypertension.更多还原