【摘要】 目的　探讨肿瘤坏死因子 -α(TNF -α)与 2型糖尿病胰岛素的关系。方法　用homa -R法选取有胰岛素抵抗 (IR组 )和无胰岛素抵抗 (NIR组 )的 2型糖尿病患者各 2 0例。另以 2 0名年龄及体重指数相匹配的人群的作为对照组 ,分别检测其空腹血糖、胰岛素 ,计算Homa -R值 ,用ELISA法检测TNF -α。结果　IR组的TNF -α与NIR组及对照组相比较明显增高 ,有统计学意义(P <0 0 5 ) ,IR组的空腹胰岛素水平及胰岛素抵抗指标Homa -R也显著高于NIR组及对照组 (P值为 <0 0 1) ,而三组间年龄、BMI、血脂、脂蛋白、血压均无显著性差异 (P >0 0 5 )。结论　血浆TNF -α水平与胰岛素抵抗呈密切相关 ,在 2型DM中有重要病理意义 ,可作为评估有无胰岛素抵抗的一项重要参考指标更多还原

【Abstract】 Objective To study the relationship between serum level of tumor necrosis factor-α(TNF-α)and insulin resistance in patients with type 2 diabetes. Methods by using the homeostasis model assessment (Homa-R), 20 patients with insulin resistance(IR group) and 20 patients with non-insulin resistance(NIR group) were selected in this study, and 20 age and BMI-matched healthy subjects were also recruited as control group. Serum levels of insulin, TNF-α, lipids, apolipoprotein and glucose were measured after overnight fasting. Results The serum level of TNF-α was significantly higher in the patients of IR group than that in the patients of NIR group and the subjects of control group(P<0 05), and fasting serum insulin and Homa-R were also significantly higher in the patients of IR group than those in the patients of NIR group and the subjects of control group(P<0 01). There were not significant differences in mean values of BMI, age, lipids, apolipoprotein and blood pressure among the 3 groups. Conclusion The serum level of TNF-α was related with insulin resistance and involved in the pathogenesis of Type 2 diabetes, and it may serve as an index to evaluate insulin resistance in patients with type 2 diabetes.更多还原