【摘要】 目的　研究NF -κB与膀胱癌分级、分期、复发及转移的关系 ,以及NF -κB和PKC的关系。方法　采用免疫组化SP法检测NF -κB和PKC在膀胱移行细胞癌石蜡包埋标本 5 4例和正常对照标本 13例的表达。结果　NF -κBP65和PKC在 5 4例膀胱癌中的阳性表达率分别为 88 9%、81 5 %。NF -κB阳性表达率随膀胱癌分级、分期的增高有降低趋势 ,而随复发及转移的增多而增高。NF -κBP65和PKC在膀胱癌中的表达具有正相关性。结论　NF -κB可能在膀胱癌早期起促进作用。有望作为评价膀胱癌恶性度、肿瘤进展的指标。PKC在NF -κB的激活过程中有可能发挥促进作用更多还原

【Abstract】 Objective To study the correlation of NF-κB expression with the grade, the stage, the recurrence, the metastasis and PKC expression of bladder transitional cell carcinoma. Methods The expression of NF-κB and PKC was examined with SP immunohistochemical method in 54 cases of paraffin-embedded bladder transitional cell carcinomas tissues and 13 cases of normal bladder tissues. Results The positive expression rate of NF-κB P65 and PKC in bladder transitional cell carcinomas was 88 9% and 81 5% respectively. The expression rate of NF-κB decreased along with pathological grade and clinical stage increased, while its expression increased along with the rate of recurrence and metastasis elevated. There was a positive relationship between NF-κB and PKC expressions. Conclussion NF-κB may play a role at early stage of bladder transitional cell carcinoma. It probably serves as an index to evaluate the malignant extent and progression of bladder transitional cell carcinoma. PKC probably takes part in the activation process of NF-κB.更多还原