【摘要】 目的　研究肝炎后肝硬化病人的前白蛋白合成速率与肝功能损害的关系。方法　用首次静脉推注加恒速静脉滴注1 5N -赖氨酸示踪技术测定前白蛋白的合成速率。结果　通过对 12名正常人和 2 3名肝硬化病人的测定发现 :肝炎后肝硬化病人的人体前白蛋白合成速率明显降低 ,并与肝损害程度显著相关。结论　该方法测定血浆前白蛋白合成率 ,用于探讨肝炎后肝硬化时肝脏本身蛋白质代谢障碍 ,及从动态角度认识和评价肝功能 ,为肝炎后肝硬化的研究提供了一项新的测定方法更多还原

【Abstract】 Objective To explore the correlation between the prealbumin synthetic rate and liver function damage in patients with liver cirrhosis resulted from hepatitis. Methods The prealbumin synthetic rate was measured using isotope tracer technique of 15 N-lysine injected by intravenous followed by intravenous drop at constant rate in 23 patients with liver cirrhosis and 12 healthy subjects. Results Prealbumin synthetic rate in the patients decreased significantly than that in normal control(P<0 05). A positive correlation between liver function damage and the prealbumin synthetic rate was observed. Concludions The prealbumin synthetic rate assay can be served as a new method in the study of post-hepatitis liver cirrhosis and the hepatic protein metabolism dysfunction, and general liver function in these patients can be monitored by dynamic inspection of prealbumin synthetic rate.更多还原