【摘要】 目的　研究鼻咽癌 (NPC)患者放疗后听觉诱发 (ABR)的改变及原因。方法　 5 6例鼻咽癌患者在放疗前、放疗中 (36～ 4 0Gy)、放疗后 3、6、1 2个月进行脑干听觉诱发 (ABR)的检测。分析 (ABR)改变与患者年龄、是否合并糖尿病或高血压或冠心病以及肿瘤T分期的关系。结果　鼻咽癌放疗后 1 2个月 (ABR)中异常率为 71 .4 %。放疗中 (鼻咽DT36～ 4 0Gy)、放疗结束以及结束后 3、6、1 2个月异常率分别 1 6 .0 % (9/ 5 6 )、2 8.6 % (1 6 / 5 6 )、30 .4 % (1 7/ 5 6 )、4 4 .6 % (2 5 / 5 6 )、71 .4 % (4 0 / 5 6 )。年龄 <5 0岁、>5 0岁分别为 5 4 .2 % (1 3/ 2 4 )、84 .4 % (2 7/ 32 ) ,差异有显著性 (χ2 =5 .9,P <0 .0 5 )。伴有糖尿病和 /或高血压、冠心病的患者ABR异常率为 84 .6 % (2 2 / 2 6 ) ,显著高于无此类疾病患者 6 0 % (1 8/ 30 ) (χ2 =4 .1 4 ,P <0 .0 5 )。T分期中伴咽旁间隙受侵和 /或颅底侵犯T3 、T4期患者 ,异常率为 81 .6 % (31 / 38) ,而T1 、T2 期无咽旁及颅底受侵者为 5 0 % (9/ 1 8) ,两者相比有显著性差异 (χ2 =5 .97,P <0 .0 5 )。结论　鼻咽癌放疗后ABR改变与患者年龄、伴随疾病以及临床分期有关更多还原

【Abstract】 Objective To study the factors influencing the change of brainstem auditory evoked potential in nasopharyngeal carcinoma(NPC) patients after radiotherapy.Methods Fifty six patients with nasopharyngeal Carcinoma were examined through brainstem auditory evoked potential before radiotherapy within the period of radiotherapy(36 40Gy/3 4w) and at immediately,three,six,twelve month after radiotherapy.The changes of ABR among the ages of patients,the diabetes and /or hypertensive diseases and/or coronary atherosclerotic heart disease,the clinical T stages were analysed.Results The total abnormity rates of ABR within twelve months after radiotherapy was 71.4%(40/56).The abnormity rates of ABR within the period of radiotherapy (36 40Gy/3 4w) and at immediately,three,six and twelve month after radiotherapy were 16.0%(9/56),28.6%(16/56),30.4%(17/56),44.6%(25/56),71.4%(40/56),respectively.The abnormity rate of patients less than 50 years old and more than 50 years old were 54.2%(13/24),84.4%(27/32)( P <0.05).The abnormity rate of patients with diabetes and/or coronary atherosclerotic heart disease (CHD) and/or hypertensive disease were 84.6%(22/26),compared with those free of these disases were 60%(18/30),the difference was statistically significant ( P <0.05).The parapharyngeal and/or skull base invasion and high T stage lesion were risk factors for the abnormity rate of ABR ( P <0.05).Conclusion The study shows the change of ABR in NPC patients after radiotherapy concerns with other chronic diseases,T stage and age.更多还原