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PLGA/TCP 材料的浓度-粘度性能研究

Research on Concentration-Viscosity of PLGA/TCP for Bone Tissue Engineering

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【作者】 向虎费小琛卢清萍颜永年熊卓林峰尹曦

【Author】 XIANG Hu FEI Xiaochen LU Qingping YAN Yongnian XIONG Zhuo LIN Feng YIN Xi (Department of Mechanical Engineering,Tsinghua University,Beijing 100084,China)

【机构】 清华大学机械工程系清华大学机械工程系 北京 100084北京 100084

【摘要】 为研究骨组织工程材料的成形性能。基于低温沉积制造工艺,研究了 PLGA/TCP 配制成浆料的浓度、粘度对成形性的影响。首先测定了材料的粘度随浓度的变化关系,然后对不同浓度的材料进行成形,发现材料的粘度对宏观成形效果起着决定性的作用,同时浓度变化使试样的微观结构具有较大差异。因此,可以通过控制浓度即粘度来调整试样的宏观、微观成形效果。

【Abstract】 In order to make research on the forming property,the relations among temperature,viscosity andforming property of the composite of PLGA/TCP are discussed,based on the process of Low-temperature DepositionManfacturing(LDM).Firstly the relation between concentration and viscosity is studied.The materials of various con-centration are formed,through which it can be seen that the viscosity is the key factor for the macroscopical impres-sion,but microcosmic structures are quite different relative to the concentration.So,it is concluded that the macrocos-mic and microcosmic requirements can be satisfied by adjusting the concentration which can lead to necessary viscosi-ty.

【基金】 清华大学基础研究基金(重点):JZ2002001
  • 【分类号】R318.08
  • 【被引频次】6
  • 【下载频次】193
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