【摘要】 目的 :研究健康大学生血清乙型肝炎病毒 (HBV )感染状况及变化趋势。方法 :用酶联免疫吸附实验测大学生血清中HBV抗原 抗体系统 ,赖氏法检测丙氨酸转氨酶 (ALT)活性 ,问卷调查入学时学生使用乙肝疫苗的情况。结果 :1996— 2 0 0 0年 5届学生入学时感染模式 1感染率逐年下降 ,感染模式 2感染率逐年升高 ,感染模式 3感染率逐年下降但变化不明显 ;使用乙肝疫苗后产生的抗 HBs入学时维持率为 77 36 % ,少数个体对乙肝疫苗并不敏感 ;感染模式 1学生接受乙肝疫苗全程免疫 1次 ,抗 HBs阳性率与入学前使用乙肝疫苗有一定关系。结论 :各感染模式的感染率呈时间变化 ,ALT异常者应引起高度重视 ;注射乙肝疫苗对机体产生保护性抗体 ,抗 HBs作用明显 ,乙肝疫苗不敏感的人群可能确实存在。更多还原

【Abstract】 Objective:To analyse the change trend of hepatitis B virus(HBV) infection serum status and vaccination against hepatitis B in healthy university students.Methods:The HBV serum marker of 3001 new university students was detected by enzyme linked immunosorbent assay,and serum elevated alanine amino-transferase (ALT) was measured by automatic biochemistry analysis instrument.The condition of vaccination against HBV was investigated by visiting every university student at the time of entrance.Results:In 3001 new university students from 1996 to 2000,the positive rate of infection model 1 was decreasing,and infection model 2 was increasing,and infection model 3 was not clear reduced with year by year.77.36% students have still retained positive anti-HBs(Antibody to HBsAg) after vaccination against hepatitis B,but it was sure that a small number of population wasn’t susceptible to HBV vaccine.The students with infection model 1 anti-HBS positive rate after inoculation for a complete term were related to inoculated HBV vaccine ever.Conclusion:All of the infection rate in every infection model was changed as time goes on,the population of abnormal ALT must be valued.It is very useful to product anti-HBs by inoculated HBV vaccine,and it is possible that a small amount of population isn’t sensitive to HBV-vaccine.更多还原