【摘要】 以亚磷酸二乙酯为原料 ,经多步反应合成了亚乙烯基二膦酸 (EDP)配体 .通过1 HNMR测定进行了结构确认 ;经99mTc标记后 ,标记率高于 95% .体外稳定性测定表明 ,6h后放化纯度仍保持在 90 %以上 .小鼠体内分布实验表明 ,99mTc EDP与99mTc MDP( 99mTc 亚甲基二膦酸 )均具有较强的亲骨性能 ,99mTc EDP骨摄取优于99mTc MDP ,并且随着时间的增加 ,骨与非靶器官摄取的比值都在增加 ,远远高于99mTc MDP .进行了狗SPECT全身骨显像实验 ,2h后获得清晰的图像 .更多还原

【Abstract】 Ethenylidenebisphosphonate(EDP)is synthesized successfully from the initial compound, diethyl phosphate. Its structure is determined by 1HNMR. The labelling yields of 99mTc-EDP is more than 95% under the selected labelling condition. The stability study of 99mTc-EDP indicates that its radiochemistry purity is more than 90% after 6 h. The study of the biodistribution in mice of 99mTc-EDP demonstrates that 99mTc-EDP and 99mTc-MDP all have a high bone uptake, and the bone uptake of 99mTc-EDP exceeds 99mTc-MDP and it improves with the time going as well as the ratio between of bone and other organ, which also is farthest higher than 99mTc-MDP. The whole body bone imaging in dog by SPECT is studied after injecting 99mTc-EDP. The results indicate very clear scintigraphic images obtained for 99mTc-EDP at 2 h p.i..更多还原