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糖基化终产物诱导肾系膜细胞CTGF mRNA表达的规律

Pattern of CTGF mRNA expression induced by advanced glycation end products in mesangial cells

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【作者】 周桂华李才苗春生

【Author】 ZHOU Gui-hua, LI Cai , MIAO Chun-sheng (Department of Pathology, Institute of Frontier MedicalSciences, Jilin University, Changchun 130021, China)

【机构】 吉林大学再生医学科学研究所病理研究室吉林大学再生医学科学研究所病理研究室 吉林长春130021吉林长春130021吉林长春130021

【摘要】 目的 :探讨糖基化终末产物 (AGEs)对大鼠肾系膜细胞结缔组织生长因子 (CTGF) m RNA表达的影响。方法 :在体外培养的大鼠肾系膜细胞培养基中 ,分别加入不同浓度的糖化牛血清白蛋白 (AGE- BSA)及牛血清白蛋白 (BSA) ,RT- PCR法检测细胞转化生长因子β1 (TGF-β1 )和结缔组织生长因子 (CTGF) m RNA表达。结果 :与加入 BSA组比较 ,AGE- BSA组 TGF-β1 和 CTGF m RNA表达明显增强 (P<0 .0 1) ,TGF-β1 m RNA表达增强发生时间早于 CTGF。结论 :AGEs能明显诱导肾系膜细胞 CTGF m RNA表达上调 ,并且具有时间和剂量依赖性。

【Abstract】 Objective To explore the effects of advanced glycosylation end products on the mRNA expression of connective tissue growth factor(CTGF) in rat mesangial cells. Methods Rat mesangial cells were cultured in vitro under standard conditions. After stimulated by AGE-BSA and BSA, respectively, RNA was extracted and TGF-β 1 and CTGF mRNA were assessed by RT-PCR. Results TGF-β 1 and CTGF mRNA were significantly upregulated by AGE-BSA in time- and dose-dependent manner compared with control BSA. AGE-BSA induced TGF-β 1 mRNA expression earlier than CTGF mRNA. Conclusion AGEs can significantly induce TGF-β 1 and CTGF mRNA expressions in cultured mesangial cells in time- and dose-dependent manner.

【基金】 国家自然科学基金资助课题 (39870 312 )
  • 【文献出处】 吉林大学学报(医学版) ,Journal of Jilin University of (Medicine Edition) , 编辑部邮箱 ,2004年05期
  • 【分类号】R587.2
  • 【被引频次】5
  • 【下载频次】87
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