【摘要】 本文用RIA测定 2 1例正常血压和 4 1例高血压的老年男性肥胖和非肥胖患者血清瘦素和胰岛素的含量。结果显示 :高血压非肥胖组与正常血压非肥胖组的血清瘦素和胰岛素的含量变化无显著性 ;高血压肥胖组瘦素和胰岛素含量较正常血压肥胖组分别平均升高 1 .8μg/L和 2 .7mIU/L(P <0 .0 1 ) ;高血压肥胖组较高血压非肥胖组瘦素和胰岛素含量分别平均升高 2 .7μg/L和 4 .7mIU/L(P <0 .0 0 1 ) ;胰岛素敏感指数在高血压肥胖组、正常血压肥胖组、高血压非肥胖组、正常血压非肥胖组中依次递减 (相对ISI分别为 0 .5 0 ,0 .6 8,0 .92 ,1 )。提示 :老年男性高血压肥胖患者中存在瘦素抵抗和胰岛素抵抗 ,瘦素与伴肥胖的高血压有密切关系。更多还原

【Abstract】 To study the contents of serum leptin and insulin in elderly male patients with obesity-related hypertension, the levels of serum leptin and insulin in 21 normotensive cases and 41 hypertensive cases of them were determined by RIA.The results showed that the levels of serum leptin and insulin between hypertensives and normotensives in the non-obese groups were not significantly different( P >0.05).Compared with normotensives, the levels of serum leptin and insulin of hupertensives in the obese groups remarkablely increased 1.8μg/L and 2.7mIU/L respectively( P <0.01).The levels of serum leptin and insulin in the patients with obesity-related hypertension were markedly higher than those in the patients with non-obesity-related hypertension and elevated 2.7μg/L and 4.7mIU/L( P <0.01) respectively.Insulin-sensitivity index(ISI) successively decreased in the groups of HBPOb, NBPOb, HBPNOb and NBPNOb(relative ISI 0.50, 0.68, 0.92, 1 respectively).It is concluded that leptin-resistance and insulin-resistance exist in male elderly patients with obesity-related hypertension.更多还原